International Review of Ophthalmology

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All-trans retinoid acid and the ocular surface

YAO Wang, LE Qi-hua   

  1. Department of Ophthalmology, EYE and ENT Hospital of Fudan University, Shanghai 200031, China
  • Received:2016-04-07 Online:2017-02-22 Published:2017-02-20
  • Contact: LE Qi-hua, Email: angela_le1977@163.com
  • Supported by:

    The National Natural Science Fund Projects of China（81270014）

Abstract:

All-trans retinoid acid (ATRA) is one of the vital metabolites of vitamin A. ATRA plays a crucial role in the regulation of cellular proliferation, differentiation, and normal keratinization of ocular surface epithelium. ATRA has a potential therapeutic effect against some ocular surface cicatricial disorders such as Stevens-Johnson syndrome and diseases associated with corneal epithelial damage. ATRA is a promising tool in the treatment of allogenic graft rejection after penetrating keratoplasty and partial limbal stem cell deficiency (LSCD).   (Int Rev Ophthalmol,  2017,  41:  28-31)